DM testing - Page 5

Thanks Blitzen!

Rico, I really like  your dog on that photo. Did I see him at Statesville a few years ago or here in FL more recently? His name sounds familar.

Dogs that have tested clear have been proven to have had DM upon necropsy, how can you say your dogs are free of DM, Rico? How can you agree with that statement, Blitzen if you know better? This is one of the problems with this test, it is used for advertising, claiming dogs are free and therefore can not possibly produce dogs that will have DM.

However, the frequency of the mutation varies between breeds and certainly the risk of developing the clinical disease seems quite distinct and breed-specific. For example, the frequency of carriers and homozygous mutation (affected) dogs in the Kerry blue terrier is about 52%(1), while carriers and affected dogs make up 91% of Pembroke Welsh corgis in Japan (2). Although wire fox terriers have a similar combined carrier and at-risk frequency of 90%, none have ever developed the clinical signs of DM (3).

Wire Fox Terriers do not show DM despite having a much higher frequency of the SOD1 gene than the GSD.

https://www.pawprintgenetics.com/blog/2013/08/29/which-breeds-are-affected-degenerative-myelopathy/

Let's see the proof, Markobytes. So far, nothing but he said she said. Lets see the written autoposy reports and the results of those inaccurate DNA tests. Then you'll have something we can hang our hats on. Otherwise my opinion is ever bit as valid as yours.

Test your dogs, don't test your dogs, makes no difference whatsoever to me. I was agreeing with Rico when he/she said he tests his dog for those diseases. When did you ever hear me say that that a DM normal dog is a 100% guarantee that any dog will never produce or exhibit DM. Don't put words in my mouth. Your problem is with breeders who use DNA results incorrectly, not me. If you and your friends can't sell pups without DM DNA results, then you need to figure out a way to convince buyers that the DM tests are not necessary and/or valid.

 

http://onlinelibrary.wiley.com/doi/10.1111/jvim.12317/full

I've posted this before. Scientific study that showed multiple dogs from multiple breeds, including GSDs, that were confirmed to have DM on autopsy but tested as either clear or carrier.

I believe the claim is that some posters have personal knowledge of dogs that tested normal developing DM and the same dogs receiving different results from different labs.

Coates also provided the PDB with this report.

 

 

From the OFA website....

Summary: We recommend that dog breeders take into consideration the DM test results as they plan their breeding programs; however, they should not over-emphasize this test result. Instead, the test result is one factor among many in a balanced breeding program.

We do not even have to leave these threads to find people who overemphasize or misuse the results, that is human nature, those that created the environment for it to happen, that is the crime.

jprony, the University of Missouri had ten GSDs with confirmed cases of DM in their study when they developed this test, of these ten, seven tested at risk, two tested as carriers, and one tested clear. Dr Clemmons, while doing research at the University of Florida for the form of DM specific to GSDs explored the SOD1 gene mutation and believed the presence of the mutation to be merely casual and not causal.