For Those Who Test For DM, What Age? - Page 19

hutchins; thank you for the bullet point out line. debate is healthy, but please let's debate facts

Hundmutter, not Hutchins. 

' German Shepherd with DM disease positive  is around  1973 !! '

How were these diagnosed?

If DM should prove to be inherited as a simple recessive gene and if the test or another test proves to be accurate, that would be the best possible scenario for the breed. Eliminating quality at risks should not be part of any program, many other breeds have done that with health issues and they are regretting they did since they depleted their gene pool and are now trying to dig out of a very deep black hole. Some are at the point that they are considering petitioning to reopen their stud books. Where would this breed go to do that? Dutch Shepherds? Malis?

It will  take 3,4,5 generations of selective breeding to rid the gene pool of at risks and it will require a mighty effort by all. Given that this breed hasn't demonstrated much cooperation about anything in the past and some don't even want to be part of the research by doing something as  simple as donating DNA for banking, I have to wonder if it's ever going to happen even if the means to do so are ever at the disposal of breeders. The ball is in the breeders' court; their decision to be part of the solution or remain part of the problem.

Hundmutter and Susie - is the DM DNA test  used in  your countries the same test as the OFFA test? Do you have databases that list the results? All the results or only the normals as I understand is done in Germany? What is the reasoning behind only listing normals? How do breeders typically use those results in their breeding programs and in for sale ads? Thanks.........

OFFA data base statistics as of June 1st:

German Shepherds DNA DM -

2862 tested normal

837 tested carrier

571 tested at risk

Too bad none of the other testing labs offer a searchable database.

Joan, all were results of necropsy, I would think.

 

Blitzen - I doubt it;  but don't know for sure, without looking it up,

and I don't have time right now to do that.  I think the Germans

may also have differently organised research going on, sure Susie

will tell us.  And no I don't think there is a public results database yet

(though some DNA testing is provided by owners to the KC website).

Though I expect all scientists / researchers involved do speak with

each other, now and again, attend conferences etc.  Sadly we don't

have some internationally supplied funding 'pot' that would let

the institutions involved pool their resources into a central point.*

 

I think the main difference between people who have & are

working on DM here, and their US equivalents,  is that everyone

here seems aware it is JUST RESEARCH,  not a fully formed

and proven test, so just about nobody here advertises litters as

though the 'parents are DNA tested' or the puppies 'will be clear'. 

 

I can't really see why this took off that way, since AKC is no more

stringent about requiring Tests on breeding dogs than is our [UK] 

Kennel Club. 

 

*But then, we also have to campaign just to get the Veterinary and

the Human research people to work together to develop prosthetics

and surgical techniques, here; there is an awful lot of duplication goes

on !

Blitzen, as far as I can tell from the working-dog.eu database, only the normals are listed on the site, but that doesn't mean carriers and at risks are not listed elsewhere. I saw a note about "1 new carrier listed" on the sidebar, but couldn't navigate to it for some reason. The list I saw showed numbers tested, percentages of normals vs. carriers vs. at risks, however, only the normal dogs were published from what I could find. Curious to hear what Susie says about it; maybe I'm mistranslating. 

It´s still in the beginning, official lab is Laboklin, but there is no official databank, but people who tested for DM and the dog is N/N, write it down on their dog´s page in working dogs.eu.
DSH magazine does offer a free databank, just push the genotype N/N bottom. There are several dogs listed.
http://www.dsh-spezial.de/degm/index.php
Besides that his is everything you are able to find right now

Hund, thanks. I was asking black mal per his post, though.